Accès rapides :

Vous êtes ici :

  1. Accueil
  2. Publications et outils
  3. Bases de données
  4. Fiches toxicologiques
  5. Acide perfluorooctanoïque et ses sels (PFOA et ses sels) (FT 300) (rubrique sélectionnée)

Acide perfluorooctanoïque et ses sels (PFOA et ses sels)

Fiche toxicologique n° 300

Sommaire de la fiche

Édition : 2013

Bibliographie

  1. Perfluorooctanoic acid (PFOA) and fluorinated Telomers, US EPA PFOA stewardship program. 2010-2015 (www.epa.gov/oppt/pfoa/index.html).
  2. Perfluorooctane sulfonate (PFOS) and its salts. OECD Hazard assessment. 2002.
  3. PFOA. In : Gestis-databank on hazardous substances. BGIA, 2013 (www.dguv.de/ifa/gestis-database/index.jsp).
  4. Acide pentadécafluorooctanoïque, ses sels et ses précurseurs. Santé canada, rapport préalable. Août 2012.
  5. PFOA. Committee for Risk Assessment RAC. Opinion proposing harmonized classification and labelling at Community level of Perfluorooctanoic acid (PFOA). ECHA/RAC/DOC N° CLH-O-0000002227-78-01/F. ECHA, 2011.
  6. APFO. Dossier SVHC, adoption au Comité des états membres, juin 2013 (www.echa.europa.eu).
  7. Toxicological profile for perfluoroalkyls. ATSDR, 2009 (www.atsdr.cdc.gov/toxprofiles/index.asp).
  8. Franko J, Meade BJ, Frash HF, Barbero AM et Anderson SE - Dermal penetra­tion potential of perfluorooctanoic acid (PFOA) in human and mouse skin. J Toxicol Environ Health A. 2012 ; 75(1) : 50-62.
  9. Hinderliter PM, DeLorme MP et Kennedy GL - Perfluorooctanoic acid: Relationship between repeated inhalation exposures and plasma PFOA concentration in the rat. Toxicology. 2006 ; 222 : 80-85.
  10. AFSSA. Avis relatif aux risques potentiels pour la santé humaine liés à la présence résiduelle d'acide perfluorooctanoïque (PFOA) dans les revête­ments antiadhésifs des ustensiles de cuisson des aliments. 2007 ; Saisine n° 2007-SA-0391.
  1. Loccisano AE, Campbell JL Jr, ButenhoffJL, Andersen ME et Clewell HJ - Comparison and evaluation of pharmacokinetics of PFOA and PFOS in the adult rat using a physiologically based pharmacokinetic model. Reprod Toxicol. 2012 ; 33 : 452-467.
  2. Perfluorooctanoic acid (PFOA). In : Base de données HSDB, 2012. (www.toxnet.nlm.nih.gov/cgi-bin).
  3. Fasano WJ, Kennedy GL, Szostek B et al. - Penetration of ammonium perfluorooctanoate through rat and human skin in vitro. Drug Chem Toxicol. 2005 ; 28(1) : 79-90.
  4. EFSA (2008) - Perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and their salts. Scientific opinion of the panel on contaminants in the food chain. The EFSA Journal. 2008 ; 653 : 79-131.
  5. NHANES Fourth National Report on Human Exposure, Updated tables, CDC. March 2013, 318 p.
  6. Schulz C, Wilhelm M, Hudorf U, Kolossa-Gehring M - Update of the reference and HBM values derived by the German Human Biomonitoring Commission. Int. J. Hyg. Environ. Health. 2011 ; 215 : 26-35.
  7. Olsen GW, Logan PW, Hansen KJ, Simpson CA et al. - An occupational exposure assessment of a perfluorooctanesulfonyl fluoride production site: biomonitoring. Am Ind Hyg Assoc J, 2003 ; 64(5) : 651-659.
  8. Deutsche Forschungsgemeinschaft (DFG) - List of MAK and BAT values 2013. Maximum concentrations and biological tolerance values at the workplace. Report 49. Weinheim : Wiley-VCH Verlag ; 2013 : 299 p.
  9. Toxicological overview PFOS + PFOA. Health Protection Agency, 2009.
  10. Kennedy GL, Hall GT, Brittelli MR et al. - Inhalation toxicity of ammonium perfluorooctanoate. Food Chem Toxicol. 1986 ; 24(12) : 1325-1329.
  11. Kinney LA, Chromey NC et Kennedy Jr GL - Acute inhalation toxicity of ammonium perfluorononanoate. Food Chem Toxicol. 1989 ; 21(1) : 46-68.
  12. Kennedy GL - Dermal toxicity of ammonium perfluorooctanoate. Toxicol Appl Pharmacol. 1985 ; 81(2) : 348-355.
  13. Griffith FD et Long JE - Animal toxicity studies with ammonium perfluoro­octanoate. Am Ind Hyg Assoc J. 1980 ; 41(8) : 576-583.
  14. DeWitt JC, Copeland CB, Strynar MJ et Luebke RW - Perfluorooctanoic acid-induced immunomodulation in adult C57BL/6J or C57BL/6N female mice. Environ Health Perspect. 2008 ; 116(5) : 644-650.
  15. Post GB, Cohn PD et Cooper KR - Perfluorooctanoic acid (PFOA), an emerging drinking water contaminant: a critical review of recent literature. Environ Res. 2012 : 116 ; 93-117.
  16. Klaunig JE, Hocevar BA et Kamendulis LM - Mode of action analysis of perfluorooctanoic acid (PFOA) tumorigenicity and human relevance. Reprod Toxicol. 2012 ; 33(4) : 410-418.
  17. Bjork JA, ButenhoffJL et Wallace KB - Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes. Toxicology. 2011 ; 288 : 8-17.
  18. Yang Q, Xie Y, Alexson SE, Nelson BD et DePierre JW - Involvement of the peroxisome proliferator-activated receptor alpha in the immuno­modulation caused by peroxisome proliferators in mice. Biochem Pharmacol. 2002 ; 63(10) : 1893-1900.
  19. Abbott BD, Wolf CJ, Schmid JE et al. - Perfluorooctanoic acid (PFOA)- induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha. Toxicol Sci. 2007 ; 98(2) : 571-581.
  20. Yang Q, Xie Y, Eriksson AM, Nelson BD et DePierre JW - Further evidence for the involvement of inhibition of cell proliferation and development in thymic and splenic atrophy induced by the peroxisome proliferator per- fluoroctanolc acid in mice. Biochem Pharmacol. 2001 ; 62(8) : 1133-1140.
  21. Qazi MR, Abedi MR, Nelson BD, DePierre JW et Abedi-Valugerdi M - Dietary exposure to perfluorooctanoate or perfluorooctane sulfonate induces hypertrophy in centrilobular hepatocytes and alters the hepatic immune status in mice. Inter Immunopharmacol. 2010 ; 10 : 1420-1427.
  22. Son HY, Kim SH, Shin HI, Bae HI et Yang JH - Perfluorooctanoic acid- induced hepatic toxicity following 21-day oral exposure in mice. Arch Toxicol. 2008 ; 82(4) : 239-246.
  23. Liu RC, Hurtt ME, Cook JC et Biegel LB - Effect of the peroxisome prolife­rator, ammonium perfluorooctanoate (C8), on hepatic aromatase activity in adult male Crl:CD BR (CD) rats. Fundam Appl Toxicol. 1996 ; 30(2) : 220­228.
  24. Perkins RG, ButenhoffJL, Kennedy GL et al. - 13-Week dietary toxicity study of ammonium perfluorooctanoate (APFO) in male rats. Drug Chem Toxicol. 2004 ; 27(4) : 361-378.
  25. Loveless SE, Finlay C, Everds NE et al. - Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO). Toxicology. 2006 ; 220(2-3) : 203-217.
  26. Iwai H et Yamashita K - A fourteen-day repeated dose oral toxicity study of APFO in rats. Drug Chem Toxicol. 2006 ; 29(3) : 323-332.
  27. Yang Q, Xie Y et DePierre JW - Effects of peroxisome proliferators on the thymus and spleen of mice. Clin Exp Immunol. 2000 ; 122(2) : 219-226.
  28. Yang Q, Abedi-Valugerdi M, Xie Y et al. - Potent suppression of the adaptive immune response in mice upon dietary exposure to the potent peroxisome proliferator, perfluorooctanoic acid. Int Immunopharmacol. 2002 ; 2(2-3) : 389-397.
  29. Fairley KJ, Purdy R, Kearns S, Anderson SE et Meade BJ - Exposure to the immunosuppressant, perfluorooctanoic acid, enhances the murine IgE and airway hyperreactivity response to ovalbumin. Toxicol Sci. 2007 ; 97(2) : 375-383.
  30. Oda Y, Nakayama S et Harada K - Negative results of umu genotoxicity test of fluorotelomer alcohols and perfluorinated alkyl acids. Environ Health Prev Med. 2007 ; 12 : 217-219.
  31. Jacquet N, Maire MA, Rast C, Bonnard M et Vasseur P - Perfluorooctanoic acid (PFOA) acts as a tumor promoter on Syrian hamster embryo (SHE) cells. Environ SciPollut Res. 2012 ; 19 : 2537-2549.
  32. Yao X et Zhong L - Genotoxic risk and oxidative DNA damage in HepG2 cells exposed to perfluorooctanoic acid. Mutat Res. 2005 ; 587(1-2) : 38-44.
  33. Takagi A, Sai K, Umemura T, Hasegawa R et Kurokawa Y - Short-term exposure to the peroxisome proliferators, perfluorooctanoic acid and perfluorodecanoic acid, causes significant increase of 8-hydroxydeoxygua- nosine in liver DNA of rats. Cancer Lett. 1991 ; 57(1) : 55-60.
  34. Biegel LB, Hurtt ME, Frame SR, O'Connor JC et Cook JC - Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats. Toxicol Sci. 2001 ; 60(1) : 44-55.
  35. ButenhoffJL, Kennedy GL Jr, Frame SR, O'Connor JC et York RG - The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat. Toxicology. 2004 ; 196(1-2) : 95-116.
  36. Wolf CJ, Fenton SE, Schmid JE, Calafat AM et al. - Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures. Toxicol Sci. 2007 ; 95(2) : 462-473.
  37. Abbott BD, Wood CR, Watkins AM, Tatum-Gibbs K et al. - Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator- activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues. Reprod Toxicol. 2012 ; 33(4) : 491-505.
  38. Yahia D, El-Nasser MA, Abedel-Latif M, Tsukuba C et al. - Effects of perfluorooctanoic acid (PFOA) exposure to pregnant mice on reproduction. J Toxicol Sci. 2010 ; 35(4) : 527-533.
  39. Lau C, Thibodeaux JR, Hanson RG, Narotsky MG et al. - Effects of perfluorooctanoic acid exposure during pregnancy in the mouse. Toxicol Sci. 2006 ; 90(2) : 510-518.
  40. Suh CH, Cho NK, Lee CK, Lee CH et al. - Perfluorooctanoic acid-induced inhibition of placental prolactin-family hormone and fetal growth retardation in mice. Mol Cell Endocrinol. 2011 ; 337(1-2) : 7-15.
  1. White SS, Calafat AM, Kuklenyik Z, Villanueva L et al. - Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring. Toxicol Sci. 2007 ; 96(1) : 133-144.
  2. White SS, Fenton SE et Hines EP - Endocrine disrupting properties of perfluorooctanoic acid. J. Steroid Biochem Mol Biol. 2011 ; 127(1-2) : 16-26.
  3. Macon MB, Villanueva LR, Tatum-Gibbs K, Zehr RD et al. - Prenatal perfluorooctanoic acid exposure in CD-1 mice: low-dose developmental effects and internal dosimetry. Toxicol Sci. 2011 ; 122(1) : 134-145.
  4. Zhao Y, Tan YS, Strynar MJ, Perez G et al. - Perfluorooctanoic acid effects on ovaries mediate its inhibition of peripubertal mammary gland develop­ment in Balb/c and C57Bl/6 mice. Reprod Toxicol. 2012 ; 33 : 563-576.
  5. Hu Q, Franklin JN, Bryan I, Morris E et al. - Does developmental exposure to perfluorooctanoic acid (PFOA) induce immunopathologies commonly observed in neurodevelopmental disorders? Neurotoxicology. 2012 ; 33(6) : 1491-1498.
  6. Olsen GW, Gilliland FD, Burlew MM, Burris JM et al. - An epidemiologic investigation of reproductive hormones in men with occupational expo­sure to perfluorooctanoic acid. J. Occup. Env. Med., 1998 ; 40(7) : 614-622.
  7. Olsen GW, Ehresman DJ, Betsy D, Buehrer MD et al. - Longitudinal assessment of lipid and hepatic clinical parameters in workers involved with the demolition of perfluoroalkyl manufacturing facilities. J. Occup. Env. Med. 2012 ; 54(8) : 974-983.
  8. Ji K et al. - Serum concentrations of major perfluorinated compounds among the general population in Korea: dietary sources and potential impact on thyroid hormones. Env. International. 2012 ; 45 : 78-85.
  9. Knox S, Jackson T, Frisbee JS, Javins B et al. - Perfluorocarbons exposure, gender and thyroid function in the C8 health project. J. Toxicol.Sci. 2011 ; 36(4) : 403-410.
  10. Knox S, Jackson T, Javins B, Frisbee SJ et al. - Implications of early menopause in women exposed to perfluorocarbons. J. Clin. Endocrinol. Metab. 2011 ; 96 : 1747-1753.
  11. Steenland K, Fletcher T, Savitz DA - Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA). Environ Health Perspect. 2010 ; 118(8) : 1100-1118.
  12. Gilliland FD, Mandel JS - Mortality among employees of a perfluoro­octanoic acid production plant. J. Occup. Med. 1993 ; 35(9) : 950-954.
  13. Leonard RC, Kreckman KH, Sakr CJ, Symons M - Retrospective cohort mortality study of workers in a polymer production plant including a reference population of regional workers. Ann. Epidemiol. 2008 ; 18 : 15-22.
  14. Lundin JI, Alexander BH, Olsen GW, Church TR - Ammonium perfluoro- octanoate production and occupational mortality. Epidemiology. 2009 ; 20(6) : 921-8.
  15. Eriksen KT, Sorensen M, McLaughlin JK, Lipworth L et al. - Perfluoro- octanoate and Perfluorooctanesulfonate Plasma levels and risk of cancer in the general danish opulation. J. Natl. Cancer Inst. 2009 ; 101 : 605-609.
  16. Bonefeld-Jorgensen AC, Long M, Bossi R, Ayotte P et al. - Perfluorinated compounds are related to breast cancer risk in Greenlandic Inuit: A case control study. Environmental Health. 2011 ; 10 : 88.
  17. Vieira VM, Hoffman K, Shin HM, Weinberg JM et al. - Perfluorooctanoic acid exposure and cancer outcomes in a contaminated community: a geographic analysis. Environ. Health Perspect. 2013 ; 121(3) : 318-23.
  18. Steenland K, Woskie S - Epidemiologic cohort mortality study of workers exposed to perfluorooctanoic acid (PFOA). American Journal of Epidemiology. 2012 ; 276(10) : 909-917.
  19. Toft G, Jonsson BA, Lindh CH, Giwercman A et al. - Exposure to perfluo­rinated compounds and human semen quality in arctic and European populations. Hum Reprod. 2012 ; 27(8) : 2532-2540.
  20. Joensen UN, Veyrand B, Antignac JP, Blomberg Jensen M et al. - PFOS (perfluorooctanesulfonate) in serum is negatively associated with testosterone levels, but not with semen quality, in healthy men. Hum Reprod. 2013 ; 28(3) : 599-608.
  21. Vestergaard S, Nielsen F, Andersen AM, Hjolund NH et al. - Association between perfluorinated compounds and time to pregnancy in a prospective cohort of Danish couples attempting to conceive. Hum Reprod. 2012 ; 27(3) : 873-880.
  22. Whitworth KW, Haug LS, Baird DD, Becher G et al. - Perfluorinated compounds and subfecundity in pregnant women. Epidemiology. 2012 ; 23(2) : 257-63.
  23. Olsen GW, Butenhoff JL, Zobel LR - Perfluoroalkyl chemicals and human fetal development: an epidemiological review with clinical and toxicological perspectives. Reproductive Toxicology. 2009 ; 27 : 212-230.
  24. Apelberg BJ, Witter FR, Hebstman JB, Calafat AM et al. - Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluoro- octanoate (PFOA) in relation to weight and size at birth. Environ Health Perspect. 2007 ; 115(11) : 1670-1676.
  25. Washino N, Saijo Y, Sacaki S, Kato S et al. - Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth. Environ Health Perspect. 2009 ; 117(4) : 660-667.
  26. Andersen CC, Fei C, Gamborg M, Nohr EA, Sprensen TI, Olsen J - Prenatal exposures to perfluorinated chemicals and anthropometric measures in infancy. American Journal of Epidemiology. 2010 ; 172(11) : 1230-1237.
  27. Chen MH, Ha EH, Wen TW, Su YN et al. - Perfluorinated compounds in umbilical cord blood and adverse birth outcomes. PLoS ONE. 2012 ; 7(8) : 1-7.
  28. Fei C, McLaughlin JK, Tarone RE, Olsen J - Perfluorinated chemicals and fetal growth: a study within the Danish National Birth Cohort. Environ Health Perspect. 2007 ; 115(11) : 1677-1682.
  29. Fei C, McLaughlin JK, Tarone RE, Olsen J - Fetal growth indicators and perfluorinated chemicals: a study in the Danish National Birth Cohort. American Journal of Epidemiology. 2008 ; 168(1) : 66-72.
  30. Fei C, McLaughlin JK, Lipworth KL, Olsen J - Maternal levels of perfluorinated chemicals and subfecondity. Hum Reprod. 2009 ; 24(5) : 1200-1205.
  31. Fei C, Olsen J - Prenatal exposure to perfluorooctanoate chemicals and behavioral or coordination problems at age 7 years. Environ Health Perspect. 2011 ; 119 : 573-578.
  32. Stein CR, Savitz DA, Dougan M - Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome. American Journal of Epidemiology. 2009 ; 170(7) : 837-846.
  33. Cuves et réservoirs - Recommandation CNAMTS R 435. Paris : INRS ; 2008.

 

EN SAVOIR PLUS SUR LES FICHES TOXICOLOGIQUES