Accès rapides :

Vous êtes ici :

  1. Accueil
  2. Publications et outils
  3. Bases de données
  4. Fiches toxicologiques
  5. Phtalate de benzyle et de butyle (FT 317) (rubrique sélectionnée)

Phtalate de benzyle et de butyle

Fiche toxicologique n° 317

Sommaire de la fiche
Fiche complète (PDF 266,62 Ko) Fiche synthétique (PDF 75,87 Ko)
Nouvelle recherche

Édition : Juillet 2017

Bibliographie

  1. Butyl Benzyl Phthalate. In : HSDB. NLM, 2015 (https://www.toxnet.nlm.nih.gov/).
  2. Benzyl Butyl Phthalate. In: Gestis-databank on hazardous substances. BGIA, 2014 (http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp).
  3. Benzyl butyl phthalate. European Union Risk Assessment Report on benzyl butyl phthalate (BBP). Vol 76. European Chemicals Bureau, 2007 (https://echa.europa.eu/fr/information-on-chemicals).
  4. Phtalate de butyle et de benzyle. In : Répertoire toxicologique. CNESST, 2017 (http://www.csst.qc.ca/prevention/reptox/pages/repertoire-toxicologique.aspx).
  5. Benzyl butyl phthalate. Dossier d’enregistrement REACH, ECHA (https://echa.europa.eu/fr/information-on-chemicals).
  6. Benzyl Butyl Phthalate. In : Gestis International Limit Values (http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp).
  7. Butylbenzyl-phtalate (BBzP). In : "Valeurs limites d’exposition en milieu Professionnel, Le butylbenzyl-phtalate". ANSES, mai 2017 (https://www.anses.fr/fr/system/files/VLEP2012SA0224Ra.pdf).
  8. Phtalate de benzyle et de butyle M-168. In : MétroPol. Métrologie des polluants. INRS, novembre 2015 (https://www.inrs.fr/publications/bdd/metropol.html).
  9. Phtalate de benzyle et de butyle M-172. In : MétroPol. Métrologie des polluants. INRS, novembre 2015 (https://www.inrs.fr/publications/bdd/metropol.html).
  10. Evaluation du risque incendie dans l'entreprise. Guide méthodologique ED 970. INRS ; 2012 (https://www.inrs.fr/).
  11. Les extincteurs d'incendie portatifs, mobiles et fixes. Brochure ED 6054. INRS ; 2014 (https://www.inrs.fr/).
  12. Saillenfait A-M et Laudet A – Phtalates. EMC Toxicologie Pathologie 2. 2005 ; 1-13.
  13. Nativelle C, Picard K, Valentin I, Lhuguenot JC et al. - Metabolism of n-butyl benzyl phthalate in the female Wistar rat. Identification of new metabolites. Food Chem Toxicol. 1999 ; 37 : 905–917.
  14. Butyl benzyl phthalate. Priority Existing Chemical (PEC) assessment report no 40. National Industrial Chemicals Notification and Assessment Scheme, 2015 (https://www.nicnas.gov.au/chemical-information/pec-assessments).
  15. Elsisi AE, Carter DE et Sipes IG - Dermal absorption of phthalate diesters in rats. Fund Appl Toxicol. 1989 ; 12 : 70–77.
  16. Eigenberg DA, Bozigian HP, Carter DE et Sipes IG - Distribution, excretion, and metabolism of butylbenzyl phthalate in the rat. J Toxicol Environ Health. 1986 ; 17 : 445–456.
  17. Anderson WA, Castle L, Scotter MJ, Massey RC et al. - A biomarker approach to measuring human dietary exposure to certain phthalate diesters. Food Addit Contam. 2001 ; 18 : 1068–1074.
  18. National Report on Human Exposure to Environmental Chemicals. CDC, February 2015 (www.cdc.gov/exposurereport/).
  19. Hines CJ, Nilsen Hopf NB, Deddens JA, et al. "Urinary Phthalate Metabolite Concentrations among Workers in Selected Industries: A Pilot Biomonitoring Study." Ann Occup Hyg, 2009 ; 53(1) : 1-17.
  20. Evaluation des indicateurs biologiques d’exposition et recommandation de valeurs biologiques de référence pour le butylbenzyl-phtalate (BBzP). Avis de l'Anses, saisine 2013-SA-0104, Février 2017 (https://www.anses.fr/fr/content/les-valeurs-limites-pour-les-agents-chimiques-en-milieu-professionnel).
  21. Hammond BG, Levinskas GJ, Robinson EC et Johannsen FR - A review of the subchronic toxicity of butyl benzyl phthalate. Toxicol Ind Health. 1987 ; 3 : 79–98.
  22. Toxicology and carcinogenesis studies of butyl benzyl phthalate in F344/N rats (feed studies). National Toxicology Program Technical Report Series No. 458, NIH publication no. 97-3374, 1997 (https://ntp.niehs.nih.gov/results/pubs/index.html).
  23. Agarwal DK, Maronpot RR, Lamb JC et Kluwe WM - Adverse effects of butyl benzyl phthalate on the reproductive systems of male rats. Toxicology. 1985 ; 35 : 189–206.
  24. Barber ED, Astill BD, Moran EJ, Schneider BF et al. - Peroxisome induction studies on seven phthalate esters. Toxicol Ind Health. 1987 ; 3 : 7–24.
  25. Effect of dietary restriction on toxicology and carcinogenesis studies in F344/N rats and B6C3F1 mice. National Toxicology Program Report No. 460, 1997 (https://ntp.niehs.nih.gov/results/pubs/index.html).
  26. Carcinogenesis bioassay of butyl benzyl phthalate in F344/N rats and B6C3F1 mice (feed study). National Toxicology Program Technical Report Series No. 213, 1982 (https://ntp.niehs.nih.gov/results/pubs/index.html).
  27. Piersma AH, Verhoef A et Dortant PM - Evaluation of the OECD 421 reproductive toxicity screening test protocol using butyl benzyl phthalate. Toxicology. 1995 ; 99 : 191–197.
  28. Tyl RW, Myers CB, Marr MC, Fail PA et al. - Reproductive toxicity evaluation of dietary butyl benzyl phthalate (BBP) in rats. Reprod Toxicol. 2004 ; 18 : 241–264.
  29. Aso S, Ehara H, Miyata K, Hosyuyama S et al. - A two-generation reproductive toxicity study of butyl benzyl phthalate in rats. J Toxicol Sci. 2005 ; 30 : 39–58.
  30. Nagao T, Ohta R, Marumo H, Shindo T et al. - Effect of butyl benzyl phthalate in Sprague-Dawley rats after gavage administration: a two-generation reproductive study. Reprod Toxicol. 2000 ; 14 : 513–532.
  31. Kwack SJ, Kim KB, Kim HS et Lee BM - Comparative toxicological evaluation of phthalate diesters and metabolites in Sprague-Dawley male rats for risk assessment. J Toxicol Environ Health A. 2009 ; 72 : 1446–1454.
  32. Developmental toxicity of butyl benzyl phthalate administered in feed to CD rats on gestational day 6 to 15. National Toxicology Program Report No. 89-246, 1989 (https://ntp.niehs.nih.gov/results/pubs/index.html).
  33. Developmental toxicity of butyl benzyl phthalate in CD-1-Swiss mice. National Toxicology Program Report No. 90-114, 1990 (https://ntp.niehs.nih.gov/results/pubs/index.html).
  34. Ema M, Murai T, Itami T et Kawasaki H - Evaluation of the teratogenic potential of the plasticizer butyl benzyl phthalate in rats. J Appl Toxicol. 1990 ; 10 : 339–343.
  35. Ema M, Itami T et Kawasaki H - Evaluation of the embryolethality of butyl benzyl phthalate by conventional and pair-feeding studies in rats. J Appl Toxicol. 1991 ; 11 : 39–42.
  36. Ema M, Itami T et Kawasaki H - Teratogenic evaluation of butyl benzyl phthalate in rats by gastric intubation. Toxicol Lett. 1992 ; 61 : 1–7.
  37. Ema M, Itami T et Kawasaki H - Embryolethality and teratogenicity of butyl benzyl phthalate in rats. J Appl Toxicol. 1992 ; 12 : 179–183.
  38. Ema M, Itami T et Kawasaki H - Effect of period of exposure on the developmental toxicity of butyl benzyl phthalate in rats. J Appl Toxicol.1992 ; 12 : 57–61.
  39. Ema M, Kurosaka R, Amano H et Ogawa Y - Embryolethality of butyl benzyl phthalate during early pregnancy in rats. Reprod Toxicol. 1994 ; 8 : 231–236.
  40. Ema M, Miyawaki E et Kawashima K - Reproductive effects of butyl benzyl phthalate in pregnant and pseudopregnant rats. Reprod Toxicol. 1998 ; 12 : 127–132.
  41. Saillenfait AM, Sabaté JP et Gallissot F - Comparative embryotoxicities of butyl benzyl phthalate, mono-n-butyl phthalate and mono-benzyl phthalate in mice and rats: in vivo and in vitro observations. Reprod Toxicol. 2003 ; 17 : 575–583.
  42. Ema M, Kurosaka R, Amano H et Ogawa Y - Developmental toxicity evaluation of mono-n-butyl phthalate in rats. Toxicol Lett. 1995 ; 78 : 101–106.
  43. Ema M et Miyawaki E - Effects on development of the reproductive system in male offspring of rats given butyl benzyl phthalate during late pregnancy. Reprod Toxicol. 2002 ; 16 : 71–76.
  44. Foster PM - Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl. 2006 ; 29 : 140–147.
  45. Bornehag CG, Sundell J, Weschler CJ, Sigsgaard T et al. – The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Environ Health Perspect. 2004; 112(14): 1393-1397.
  46. Ait Bamai Y, Shibata E, Saito I, Araki A et al. – Exposure to house dust phthalates in relation to asthma and allergies in both children and adults. Sci Total Environ. 2014; 485-486: 153-163.
  47. Hsu NY, Lee CC, Wang JY, Li YC et al. – Predicted risk of childhood allergy, asthma, and reported symptoms using measured phthalate exposure in dust and urine. Indoor Air. 2012; 22: 186-199.
  48. Kolarik B, Naydenov K, Larsson M, Bornehah CG et al. – The association between phthalates in dust and allergic diseases among Bulgarian children. Environ Health Perspect. 2008; 116(1): 98-103.
  49. Calesen M, Bekö G, Weschler CJ, Sigsgaard T et al. – Associations between selected allergens, phthalates, nicotine, polycyclic aromatic hydrocarbons, and bedroom ventilation and clinically confirmed asthma, rhinoconjuncivitis, and atopic dermatitis in preschool children. Indoor Air. 2014; 24: 136-147.
  50. Calesen M, Bekö G, Weschler CJ, Langer S et al. – Phthalate metabolites in urine and asthma, allergic rhinoconjunctivitis and atopic dermatitis in preschool children. Int J Hyg Environ Health. 2014bis; 217: 645-652.
  51. Just AC, Whyatt RM, Perzanowski MS, Calafat AM et al. – Prenatal exposure to butylbenzyl phthalate and early eczema in an urban cohort. Environ Health Perspect. 2012; 120(10): 1475-1480.
  52. Stahlhut RW, van Wijngaarden E, Dye TD, Cook S et al. – Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect. 2007; 115(6): 876-882.
  53. Aschengrau A, Coogan PF, Quinn MM, Cashins LJ – Occupational exposure to estrogenic chemicals and the occurrence of breast cancer: an exploratory analysis. Am J Ind Med. 1998; 34(1): 6-14.
  54. Jönsson BAG, Richthoff J, Rylander L, Giwercman A et al. – Urinary phthalate metabolites and biomarkers of reproductive function in young men. Epidemiology. 2005; 16(4): 487-493.
  55. Duty SM, Calafat AM, Silva MJ, Ryan L et al. – Phthalate exposure and reproductive hormones in adult men. Hum Reprod. 2005; 20(3):604-610.
  56. Duty SM, Silva MJ, Barr DB, Brock JW et al. – Phthalate exposure and human semen parameters. Epidemiology. 2003; 14(3): 269-277.
  57. Hauser R, Meeker JD, Duty S, Silva MJ et al. – Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. Epidemiology. 2006; 17(6): 682-691.
  58. Buck Louis GM, Sundaram R, Sweeney AM, Schisterman EF et al. – Urinary bisphenol A, phthalates and couple fecundity, the LIFE study. Fertil Steril. 2014; 101(5): 1359-1366.
  59. Swan SH, Main KM, Liu F, Stewart SL et al. – Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect. 2005; 113(8): 1056-1061.
  60. Swan SH – Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ Res. 2008; 108(2): 177-184.
  61. Suzuki Y, Yoshinaga J, Mizumoto Y, Serizawa S et al. – Foetal exposure to phthalate esters and anogenital distance in male newborns. Int J Androl. 2012; 35: 236-244.
  62. Huang PC, Kuo PL, Chou YY, Lin SJ et al. – Association between prenatal exposure to phthalates and the health of newborns. Environ Int. 2009; 35: 14-20.
  63. Main KM, Mortensen GK, Kaleva MM, Boisen KA et al. – Human breast milk contamination with phthalates and alterations of andogenous reproductive hormones in infants three months of age. Environ Health Perspect. 2006; 114(2): 270-276.
  64. Itoh H, Iwasaki M, Hanaoka T, Sasaki H et al. – Urinary phthalate monoesters and endometriosis in infertile Japanese women. Sci Tot Environ. 2009; 408: 37-42.
  65. Weuve J, Hauser R, Calafat AM, Missmer SA et al. – Association of exposure to phthalates with endometriosis and uterine leiomyomata : findings from NHANES, 1999-2004. Environ Health Perspect. 2010; 118(6): 825-832.
  66. Whyatt RM, Liu Xinhua, Rauh VA, Calafat AM et al. – Maternal prenatal urinary phthalate metabolite concentrations and child mental, psychomotor, and behavioral development at 3 years of age. Environ Health Perspect. 2012; 120(2): 290-295.
  67. Forsberg K, Den Borre AV, Henry III N, Zeigler JP – Quick selection guide to chemical protective clothing. 6th ed. Hoboken: John Wiley & Sons ; 260 p.
  68. Phtalate de butyle et de benzyle. In : ProtecPo Logiciel de pré-sélection de matériaux de protection de la peau. INRS-IRSST, 2011 (https://protecpo.inrs.fr/ProtecPo/jsp/Accueil.jsp).
  69. Cuves et réservoirs. Interventions à l'extérieur ou à l'intérieur des équipements fixes utilisés pour contenir ou véhiculer des produits gazeux, liquides ou solides. Recommandation CNAMTS R 435. Assurance Maladie, 2008 (http://www.ameli.fr/employeurs/prevention/recommandations-textes-de-bonnes-pratiques.php).
Nouvelle recherche
EN SAVOIR PLUS SUR LES FICHES TOXICOLOGIQUES